What this means isn't clear, Thambisetty stated in an accompanying press release. But it could be that the gene variant—a variant of the complement receptor-1 gene—increases Alzheimer risk by a route other than increasing amyloid deposition in the brain. And while amyloid plaques seem to be the hallmark of Alzheimer's, a protein made by neurons, histone deacetylase 2, also seems to be involved in the Alzheimer's disease process.
To read more about this finding, see Psychiatric News. Information about Alzheimer's disease in general can be found in a new American Psychiatric Publishing book, Clinical Manual of Alzheimer Disease and Other Dementias.
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