Exercise has been found to benefit people's mental health in other ways as well. For example, the evidence is growing stronger that exercise can avert depression. See Psychiatric News. Exercise can likewise reduce amyloid plaques, the hallmark of Alzheimer's disease, in the brains of cognitively normal individuals, including those who carry the APOE-e4 gene variant—a risk factor for Alzheimer's. See that report in Psychiatric News.