Their study is the largest to date and the first to provide evidence that specific SNPs are significantly associated with a range of psychiatric disorders. In particular, they pointed to the effects of voltage-gated calcium channels on such disorders: "Our results implicate a specific biological pathway—voltage-gated calcium-channel signaling—as a contributor to the pathogenesis of several psychiatric disorders and support the potential of this pathway as a therapeutic target for psychiatric disease."
"These important findings indicate that fundamental alterations in brain development and biology can confer vulnerability to various types of mental disorders....," Jeffrey Lieberman, M.D., president-elect of APA told Psychiatric News." Overall, the study provides an important new clue about the etiology and pathogenesis of mental disorders."
APA President Dilip Jeste, M.D., also commented: "Research of this type would help in the development of future diagnostic systems in psychiatry that are based on validated biomarkers...this important study is one step in that direction."
(Image: Chepko Danich Vitalevich/Shutterstock.com)