To shed more light on this issue, Susan Shur-Fen Gau, M.D., Ph.D. a professor of psychiatry at the National Taiwan University Hospital and College of Medicine, and colleagues, looked at insurance data on 14,584 patients to link stroke risk with receptor binding profiles. They found that patients taking antipsychotics had an odds ratio of 1.60 of increased stroke risk, said Gau in the March 1 Biological Psychiatry. “The use of antipsychotics with a high binding affinity of M1 muscarinic and α2 adrenergic receptors was associated with a greater risk of stroke than the use of other types of antipsychotics,” wrote Gau. “An increased risk of stroke with antipsychotic use was noted in the patients who were older and/or who suffered from dementia.”
To read more about the use of antipsychotics in individuals with dementia, see Psychiatric News here and here.
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