"This finding has important implications for older adults, health care practitioners, scientists, and public-health experts—further demonstrating the complex interplay of mental health and genetic markers on late-life cognitive health," Rajan and his team concluded.
And in an accompanying editorial, Michelle Luciano, Ph.D., of the Center for Cognitive Aging and Cognitive Epidemiology at the University of Edinburgh, said: "Given that the APOE genotype is fixed in an individual, one of the questions that the research of Rajan et al. raises is the potential to curb cognitive decline through interventions targeting depression."
Information about the APOE e4 variant can be found in the Psychiatric News article "Disclosure of APOE Genotype Affects Memory Performance." To read more about depression in older individuals, see the Psychiatric News article "Resilience, No Depression Best Predict Successful Aging." For additional information on these topics, see Essentials of Geriatric Psychiatry, Second Edition, from American Psychiatric Publishing.