Monday, September 25, 2017

Smartphone Apps May Help Reduce Depressive Symptoms


Smartphone applications (apps) can be effective tools for improving symptoms of mild to moderate depression, reports a meta-analysis published in World Psychiatry. Apps that are entirely smartphone based and apps that provide direct feedback are associated with better results than those that require additional components or feedback from humans.

"Patients and doctors are faced with a vast array of mental health apps these days, and knowing which ones are helpful is imperative," said study co-author John Torous, M.D., co-director of the digital psychiatry program at Beth Israel Deaconess Medical Center and a chair of APA’s Smartphone App Evaluation Work Group.

Torous and his colleagues evaluated 18 clinical studies with 3,400 participants who tested mobile health apps for depressive symptoms. The 18 studies included people with clinical or self-reported depression as well as other disorders with depressive elements such as bipolar disorder, anxiety, or posttraumatic stress disorder.

Overall, the authors found that the use of a mental health app provides modest improvements in symptoms, with larger effects seen when the app was compared with an inactive control (like a waitlist) versus an active control (such as a non-mental health app). That suggests that some of the improvements are due to having a device--a sort of digital placebo. 

Benefits were also more pronounced for patients with mild to moderate depression; smartphone apps did not appear helpful for individuals with major depressive disorder, bipolar disorder, or anxiety disorders. The the data for these conditions, however, were limited.

Next, the authors separated the studies on the basis of common features to gain insight into which aspects of smartphone interventions make them effective. They found that apps delivered entirely via smartphones had significantly greater effects than those that also required external components/devices, such as downloadable training modules. Similarly, apps that provided users with specific feedback, like summary statistics and progress scores, were more effective than those without such measurements. In contrast, apps that included therapist chats or other “in-person feedback” elements had generally lower effects than those thatdid not.

“It seems counterintuitive that additional features/human feedback would decrease smartphone effectiveness,” Torous and colleagues wrote. “However, this relationship is likely due to the fact that apps not relying on external components have been designed as more comprehensive and self-contained tools.”

To read more about this topic, see the Psychiatric News article, “How Might Technology Change Mental Health Care?” Also, information about mental health apps, including APA's mobile app evaluation tool, is available here


(iStock/Cecilie_Arcurs)

Friday, September 22, 2017

Direct-to-Consumer Advertising Linked to Lower Medication Adherence


Research on direct-to-consumer advertising (DTCA) for pharmaceuticals has focused mostly on whether patients requested and physicians prescribed the featured medications. A study published in Psychiatric Services explores a new angle—whether exposure to DTCA influences adherence to medications already prescribed to people with serious mental disorders. The findings point to the importance of talking to patients about adhering to their medication regimen and encouraging them to discuss any concerns they might have as a result of reading or viewing medication ads directed to consumers.

The study found a significant association between self-reports of DTCA exposure and self-reported medication nonadherence. “Notably, the odds of being nonadherent were nearly five times greater among individuals exposed to DTCA than among those not exposed,” wrote lead author Charee E. Green, L.C.P.C., of the Department of Psychiatry and Behavioral Sciences at Johns Hopkins School of Medicine.

“Our findings highlight the importance of prescriber awareness of the many sources of information, such as listed side effects in DTCA, that affect patient decisions about their care,” according to Green and colleagues.

Participants were drawn from a pool of outpatients aged 18 years or older at a mental health clinic at Johns Hopkins Hospital in Baltimore. Front-desk staff invited patients with scheduled appointments between June 13, 2016, and July 11, 2016, to complete a brief, anonymous survey. The survey was developed by the research team to assess exposure to advertising and patients’ adherence behaviors. Nonadherence was assessed with this question: “Have you ever missed taking a prescription medication for two or more days in one week?”

Of the 630 patients seen in that period, 246 patients (39%) completed the survey. Sixty-one percent of those exposed to DTCA reported nonadherence (72 of 118 patients), compared with 26% of those not exposed (32 of 122 patients). About 48% of the respondents (118) reported exposure to DTCA, and 42% (104) reported nonadherence.

Among those exposed to DCTA and reporting medication nonadherence, 59% reported that they either changed how they took their medications or stopped taking the medication, “specifically as a result of their exposure to side-effect information.” Only 39% of these respondents waited to speak to their physician before making the changes, according to the study.

“This raises concerns about the limitations of the role of physician input in decision-making process about their treatment,” the authors wrote. “A substantial proportion (36%) did not take physician input into account at all.”

For related information, see the Psychiatric News article “AMA Calls for Ban On Advertising Directed at Consumers.”

(Image: istock/manaemedia)

Thursday, September 21, 2017

Early Exposure to Football May Have Long-Term Behavioral Consequences


A neuropsychiatric assessment of former football players has found that those who began playing the sport before the age of 12 were more likely to report symptoms of depression and apathy decades later than those who started playing after they turned 12.

This association was independent of the players' current age, duration of football play, or history of learning disabilities, suggesting that age of first exposure to football is an independent risk factor for behavioral problems. The findings were published Tuesday in Translational Psychiatry.

This analysis included 214 former amateur (high school and college players) and professional football players who were part of an ongoing study called the Longitudinal Examination to Gather Evidence of Neurodegenerative Disease (LEGEND). As part of the LEGEND study, these players were asked to take a series of annual cognitive and mood tests, including the Brief Test of Adult Cognition by Telephone (BTACT), Behavior Rating Inventory of Executive Function-Adult Version, Center for Epidemiologic Studies Depression Scale, and the Apathy Evaluation Scale.

When the investigators, led by Robert Stern, Ph.D., of the Boston University Alzheimer’s Disease and Chronic Traumatic Encephalopathy Center, divided the group based on age of first exposure (AFE) to football, they found that players with an AFE <12 had about twice the odds of having worse scores on their executive function and apathy tests, and three times the odds of elevated depression scores. There were no significant effects on overall cognition as measured with BTACT. 

Stern and colleagues did caution that while there was a robust group-level difference, there was a wide range of scores at an individual level and many players with an AFE <12 were normal. 

The findings suggest that “[y]outh exposure to football may have long-term neurobehavioral consequences,” the authors wrote. “Future longitudinal studies that objectively monitor the clinical function of youth football players throughout life, including those who do not go on to play football at the high school, college, or professional level, are ultimately needed to understand the long-term neurological safety implications of youth tackle football.”

For related information, see the Psychiatric News article “Study Finds High Prevalence of CTE, Other Disorders in Former Football Players.”

(Image: iStock/fredrocko)

Wednesday, September 20, 2017

APA Calls for Rejection of Latest Republican Effort to Repeal ACA


APA is urging members to contact their U.S. senators and voice their opposition to the Graham-Cassidy bill—the latest effort by Republicans to repeal and replace the Affordable Care Act. The bill, which was drafted by Sens. Lindsey Graham (R-S.C.) and Bill Cassidy (R-La.) and unveiled last week, appears to be gaining traction in the Senate. 

“This legislation … will lead to millions of Americans losing their health care coverage,” APA CEO and Medical Director Saul Levin, M.D., M.P.A., said Tuesday in a press release. “We are particularly concerned that this bill would make drastic cuts to the Medicaid program and roll back expansion, which has allowed 1.3 million Americans with serious mental illness and 2.8 million Americans with substance use disorder, to gain coverage for the first time. This bill harms our most vulnerable patients.”

Among its many proposals, the bill would allow states to change what qualifies as an essential health benefit, eliminating guaranteed coverage of substance use disorders and mental health treatment services. It would also stop the Affordable Care Act’s Medicaid expansion and cost-sharing subsidies and instead put that money into block grants that states could use to design their own health care systems.

“The APA is ready to work with members of both parties to craft a bipartisan solution that stabilizes the health insurance market and ensures Americans have access to quality, affordable health care,” Levin said.

Last week APA joined with five other medical specialty organizations representing more than 560,000 physicians in a letter to Senate Majority Leader Mitch McConnell and Minority Leader Charles Schumer to oppose the bill. The organizations noted that “a similar proposal was put forth by these two senators in July. Based on our analysis, the revised proposal may actually be worse than the original.”

The Republicans are up against a tight deadline of September 30 to secure the 50 votes needed to pass the measure using the budget reconciliation process. After this date, they would need 60 votes to pass the legislation. The Congressional Budget Office (CBO) on Monday announced that while it will aim to have a preliminary assessment of the Graham-Cassidy bill by early next week, it will not be able to provide point estimates of the bill’s effects on the deficit, health insurance coverage, or premiums for at least several weeks.

APA members are urged to call and email their senators today and register their opposition to the bill through a special portal on the APA website.

(Image: iStock/usschools)

Tuesday, September 19, 2017

Methylphenidate Found to Reduce Apathy in Patients With Mild Alzheimer’s Disease


Methylphenidate appears to improve apathy in patients with mild Alzheimer’s disease (AD), according to a study of community-dwelling veterans with mild AD published in AJP in Advance.

Prasad Padala, M.D., an associate director for clinical programs at the Geriatric Research Education and Clinical Center at the Central Arkansas Veterans Healthcare System, and colleagues also found that methylphenidate improved cognition, functional status, caregiver burden, Clinical Global Impression (CGI) scores, and depression.

Padala and colleagues randomized 60 community-dwelling male veterans with mild Alzheimer’s disease to methylphenidate or placebo. All participants were started on 5 mg of methylphenidate or a look-alike placebo twice daily and titrated to 10 mg twice daily at two weeks. The protocol allowed the study physician to decrease the dose if adverse events were reported. Otherwise, participants continued to take 10 mg twice daily until 12 weeks, at which time the dose was tapered to 5 mg twice daily for three days and stopped.

The primary outcome measure was the score on the clinician-reported Apathy Evaluation Scale (AES-C). The secondary outcome measures were scores on the Modified Mini-Mental State Examination and instruments evaluating cognition and function, including ability to carry out daily activities, and depression.

Padala and colleagues found significant differences over time for apathy in the methylphenidate group but not in the placebo group. After adjusting for baseline scores on the AES-C, they found that the methylphenidate group had significantly greater improvement than the placebo group at four weeks, and apathy continued to improve at eight weeks and 12 weeks. The behavioral and cognitive domains improved by eight weeks, and the emotional domain finally improved at 12 weeks. 

“These results suggest that improvement in the emotional domain may be mediated by improvements in the cognitive and behavioral domains,” Padala and colleagues wrote.

They added, “Although the ideal duration of treatment with methylphenidate is unknown, a case for longer duration can be made because the results of these studies were proportional to the duration of treatment, with the highest improvement in apathy and cognition noted with 12-week treatment. Longer duration studies need to be conducted to investigate if the improvement in apathy continues with the duration of treatment or if it plateaus at a certain point.”

For related information, see the Psychiatric News article “Kunadlini Yoga Found to Enhance Cognitive Functioning in Older Adults.”

(Image: iStock/PeopleImages)>

Monday, September 18, 2017

FDA Approves First App to Treat Substance Use Disorder


The Food and Drug Administration last week announced that it has approved the first mobile app to help treat individuals with substance use disorders (SUD). 

The app, known as Reset, uses cognitive-behavioral therapy and is intended to be used in combination with outpatient therapy to treat alcohol, cocaine, marijuana, and stimulant SUDs. The goal is to increase retention in outpatient therapy programs and promote abstinence from substance abuse. The app is not intended to be used for the treatment of opioid dependence, the FDA noted.

“This is an example of how innovative digital technologies can help provide patients access to additional tools during their treatment,” Carlos Peña, Ph.D., M.S., director of the Division of Neurological and Physical Medicine Devices in FDA’s Center for Devices and Radiological Health, said in a press release. 

The Reset app is indicated as a 12-week prescription-only adjunct treatment for patients with SUD who are not currently on opioid replacement therapy, who do not abuse alcohol solely, or who do not have an opioid use disorder. The product combines patient-facing interventions and assessments via a mobile app with clinician-facing dashboards and data analytics.

The FDA reviewed data from a multisite, unblinded 12-week clinical trial of 399 patients who received either standard treatment or standard treatment with the addition of a desktop-based version of Reset, which could be accessed at the clinic or at home. The data showed a statistically significant increase in adherence to abstinence for the patients with alcohol, cocaine, marijuana, and stimulant SUD in those who used Reset (40.3%) compared with the patients who did not (17.6%). The clinical trial did not demonstrate effectiveness of using Reset in patients reporting opioid use.

There were no reports of side effects associated with the device, according to data from the clinical studies.

With the FDA’s clearance of Reset, Pear Therapeutics (based in Boston and San Francisco), the developer of the technology, can now begin to market the app.

For related information, see the Psychiatric News article “APA to Provide Framework to Evaluate Mobile Health Apps.”

(Image: iStock/Cecilie_Arcurs)

Friday, September 15, 2017

Changes to ICD-10-CM Codes for DSM-5 Diagnoses Effective October 1


Revised 2018 ICD-10-CM codes, released by the National Center for Health Statistics (NCHS), are scheduled to take effect on October 1, 2017. The codes include new, updated, or deleted codes for diagnoses listed in ICD-10-CM, including some 65 codes related to mental health conditions listed in DSM-5. All practitioners and payers must use the codes.  

Coding updates are typically made to provide greater diagnostic specificity, which in turn impacts reimbursement levels.  

NCHS is a federal agency within the Centers for Disease Control and Prevention, which oversees the ICD-10-CM. The ICD-10 Coordination and Maintenance Committee, a federal committee co-chaired by a representative from NCHS and from the Centers for Medicare and Medicaid Services, approves proposed changes to ICD on a yearly basis. 

The coding changes that impact DSM-5 are posted on the APA website. The diagnoses are listed alongside two columns—one column listing the codes that were used through September 30, 2017, and the other column listing the new codes that will become effective October 1. Two versions of the table are provided—one listing the codes in numerical order and the other listing them in the order that they appear in DSM-5.

Thursday, September 14, 2017

CBT Provides Long-Term Benefits for Pediatric Patients With OCD


Children and adolescents with obsessive-compulsive disorder (OCD) who respond to cognitive-behavioral therapy (CBT) appear to continue to experience benefits from the therapy even after their initial course of treatment ends, according to a study published Wednesday in the Journal of the American Academy of Child and Adolescent Psychiatry.

Other research has suggested that CBT for pediatric OCD is a durable therapy, but these studies had been limited by either small samples sizes or having CBT combined with other treatments. 

For the current trial, Per Hove Thomsen, D.M.Sc., of Aarhus University in Denmark and colleagues tracked one-year outcomes in 155 youth with OCD aged 7 to 17, whose symptoms improved (Children’s Yale-Brown Obsessive-Compulsive Scale [CY-BOCS] scores ≤15) after receiving 75-minute, manualized, exposure-based CBT once a week for 14 weeks. 

During the one-year follow-up, CBT booster sessions could be given at any time, if required, with a maximum of three sessions per six-month period. About 40% of the participants had at least one booster session during the first six months, and 15% received at least one booster CBT session during the second six months.

At the one-year mark, 142 of the 155 participants still had CY-BOCS scores ≤15, and 121 had CY-BOCS scores of ≤10 (OCD remission). Only 13 of the patients, or 8%, experienced a relapse.

On average, CY-BOCS total scores dropped by 1.72 points during the first year after terminating the initial treatment, with children’s scores lowering by 1.34 points and adolescent scores dropping by 2.08 points. The authors noted that the adolescent group had a higher average CY-BOCS at the start of the study, so that may have enabled a greater reduction one year later.

“Clinically, these results imply that it is important to regularly monitor patients during the first year after successful first-line CBT,” Thomsen and colleagues wrote. “[O]ffering booster sessions to selected patients during follow-up might further strengthen the long-term effect of CBT.” 

For related information, see the Psychiatric News article “Report Highlights Alternative Treatment Options for OCD.” 

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Wednesday, September 13, 2017

Increase in Suicide Attempts Appears Driven By Young Adults With Less Formal Education, Psychiatric Disorders


An overall increase in suicide attempts from 2004-2005 to 2012-2013 appears to have disproportionately affected younger adults with less formal education and those with antisocial personality disorder, anxiety disorders, depressive disorders, and a history of violence, according to a report published today in JAMA Psychiatry.

Borderline personality disorder (BPD) continues to be the disorder most associated with suicide attempt risk, but the percentage of individuals with BPD attempting suicide dropped during the period of analysis, possibly suggesting increased access to evidence-based treatments.

Lead author Mark Olfson, M.D., M.P.H. (pictured above), of Columbia University and colleagues noted that because attempted suicide is the greatest known risk factor for completed suicide, reducing suicide attempts is an important public health and clinical goal. “The trends revealed in the study support a clinical and public health focus on young, socioeconomically disadvantaged adults, especially those who have made previous suicide attempts and those who have common mood, anxiety, and personality disorders,” he told Psychiatric News.

Olfson and colleagues used data from the 2004-2005 wave 2 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) and the 2012-2013 NESARC-III. These nationally representative surveys asked identical questions to 69,341 adults, aged 21 years and older, concerning the occurrence and timing of suicide attempts.

During the study period, the percentage of U.S. adults who reported making a recent suicide attempt increased from 0.62% in 2004-2005 to 0.79% in 2012-2013. In both surveys, most adults with recent suicide attempts were female (60.17% and 60.94% for the two periods, 2004-2005 and 2012-2013, respectively) and younger than 50 years (84.75% and 80.38%, respectively).

Statistical analysis showed significantly higher risk of suicide attempt among adults aged 21 to 34 years than among adults aged 65 and older; adults with no more than a high school education than among college graduates; and adults with antisocial personality disorder, a history of violent behavior, or a history of anxiety or depressive disorders than among adults without these conditions.

“Although we don’t understand all of the factors that are driving these trends, it may be that younger adults and adults with less education have been especially hard hit by the recent recession in terms of economic and psychological stress,” Olfson said. “Unemployed adults, those with less education, and adults with lower family incomes were all especially likely to report a recent suicide attempt.”

He called the decrease in the percentage of individuals with BPD reporting recent suicide attempt a bright spot in the study. In 2004-2005, 6.9% of adults with BPD made a suicide attempt compared with 4.57% in 2012-2013.

“This may be in part because more psychiatrists and other mental health professionals are being trained to deliver dialectical behavioral therapy,” Olfson said. 

For related information, see the Psychiatric News article “Netflix Drama About Teen Suicide Prompts Related Google Searches.”

(Image: courtesy Mark Olfson, M.D., M.P.H.) 

Tuesday, September 12, 2017

Personal Recovery Predicts Well-Being in Patients With Schizophrenia


Personal recovery—the process of developing a positive sense of self and achieving goals in spite of illness—appears to predict well-being in patients with schizophrenia spectrum disorders six months later, according to a report in Schizophrenia Bulletin. The findings point to the importance of integrating elements of personal recovery into therapy for people with schizophrenia spectrum disorders.

To examine how clinical, functional, and personal recovery contribute to well-being, Winnie W.S. Mak, Ph.D., of the Chinese University of Hong Kong and colleagues recruited patients with schizophrenia spectrum disorders from psychiatric outpatient clinics and mental health service organizations in Hong Kong.

A total of 181 participants (mean age: 31; mean duration of mental illness: 2.45 years) were included in the study; 96.6% were taking psychiatric medication. Mak and colleagues used several scales to measure patients’ positive and negative symptoms, social and occupational functioning, personal recovery (feelings of hope, optimism, self-worth, and empowerment), and well-being (positive feelings and contentment, meaningful engagement with others) at the beginning of the study and six months later.

The authors found that “[a]cross [the] three types of recovery process[es] examined, personal recovery was consistently found to be predictive of well-being above and beyond clinical symptomatology and functioning.” Additionally, the effect of personal recovery on well-being did not depend on clinical and functional recovery, which the authors noted “implies that people with schizophrenia can participate in the process of personal recovery and enjoy positive well-being regardless of their clinical stability and functional competence.”

They concluded, “Given its prominent role in promoting well-being, elements of personal recovery … should be integrated into existing therapeutic interventions and psychiatric rehabilitation services for people with schizophrenia spectrum disorders.”

For related information, see the Psychiatric News article “Psychosocial Treatments Found Effective for Early Psychosis.”


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Monday, September 11, 2017

Postpartum Depression Screening During Well-Child Visits May Improve Maternal Mental Health


Screening for postpartum depression in a well-child care setting may be an effective way to reduce maternal depressive symptoms and improve overall maternal mental health and parenting, according to a study in Pediatrics.

“Significantly fewer mothers in the intervention group were depressed at nine months postpartum compared with the care-as-usual group (0.6% vs. 2.5% for major depression),” wrote lead author Angarath I. van der Zee-van den Berg, M.D., of the University of Twente in Enschede, Netherlands and colleagues. Furthermore, these mothers scored significantly better on most maternal secondary outcomes, such as parenting and anxiety symptoms, according to the study.  

“This is a nice study that shows screening at well-child visits is feasible, and when paired with referral and treatment, may be able to reduce the incidence and consequences of maternal depression,” Jennifer Payne, M.D., director of the Women’s Mood Disorders Clinic at Johns Hopkins School of Medicine in Baltimore, told Psychiatric News.

Based on the findings, the researchers suggest that routine screening for postpartum depression in well-child care settings should be “seriously considered.” The practice would fit in well with the recommendation statement on screening for depression in adults by the U.S. Preventive Services Task Force and the 2017 recommendations for preventive pediatric health care released by the American Academy of Pediatrics in March, the study noted.

For the study, mothers visiting Dutch well-child care centers were assigned to either the intervention group (n=1,843) or care-as-usual group (n=1,246). Mothers in the intervention group were asked to complete an Edinburgh Postnatal Depression Scale (EPDS) form assessing depression symptoms before well-child care visits at one, three, and six months postpartum. During the well-child care visits, physicians scored the EPDS and discussed the outcome and any recommendations for follow-up care with the mother. Mothers in the care-as-usual group and their newborns visited the well-child care centers with the same frequency as those in the intervention group, but received no EPDS screening that guided further advice and referral.

Symptoms of depression were assessed at the beginning of the study as well as at nine months postpartum using the Mini International Neuropsychiatric Interview. Maternal anxiety, quality of parenting, health-related quality of life, and more were assessed at 12 months postpartum using the Spielberger State-Trait Anxiety Inventory, the Short Form 12-Item Health Survey, and the Maternal Self-Efficacy in the Nurturing Role questionnaire. 

“One potential flaw of the study, which limits interpretation of the results, is that the lifetime history of major depression in the intervention group was significantly lower compared to the care-as-usual group. It also would have been good to know how many women in each group received diagnoses and psychiatric interventions,” Payne noted. 

For related information, see the Psychiatric News article “Early Postpartum Depression Screenings Not Enough to Identify High-Risk Women.”

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Friday, September 8, 2017

Survey Finds Young Adults Have Highest Prevalence of Severe Mental Illness


For the first time since the Substance Abuse and Mental Health Services Administration (SAMHSA) began collecting data on the mental health and substance use of Americans, the percentage of younger adults (aged 18 to 25) in the country with severe mental illness (SMI) is greater than the percentage of SMI in adults aged 26 and older, according to the latest National Survey on Drug Use and Health (NSDUH).

At a press conference announcing the results of the 2016 NSDUH yesterday, Elinore McCance-Katz, M.D., Ph.D., assistant secretary for mental health and substance use in the Department of Health and Human Services (HHS), noted that in addition to having a higher prevalence of SMI, nearly half of young adults with SMI were not receiving proper mental health treatment. Such limited access may be contributing to the growing numbers of young adults who report thinking about, planning, and/or attempting suicide, she said. Since 2008, the rate of young adults reporting suicidal thoughts or actions has risen significantly.

The NSDUH is an annual survey of 67,500 individuals ages 12 and older across the United States. The 2016 NSDUH data indicated that 44.7 million adults in the United States had a mental illness, and 23% of these people reported a SMI that significantly impacted daily living. In 2016, 5.9% adults aged 18 to 25 had an SMI compared with 5.3% of adults aged 26 to 49 and 2.7% of adults aged 50 and up.

During the press conference, HHS Secretary Tom Price, M.D., stressed the public health impact of untreated SMI. “Ten million people each year have an SMI, they live 10 years shorter on average, and there are 10 times more people with SMI in prisons than inpatient psychiatric facilities,” he said. “It is within our power to help.”

The NSDUH survey also found that the use of illicit substances, including opioids and other psychoactive medications (such as stimulants and hypnotics), appears to have stabilized or even decreased slightly since last year’s survey. A total of 11.8 million people reported misusing opioids in 2016, for example, a decrease from 12.6 million in 2015. However, as McCance-Katz pointed out, this has not slowed the rise of drug-related deaths. For instance, heroin use has risen by 230% since 2002, but heroin-related deaths have gone up 630%. She noted that part of this rise might be due to an increased trend of drug mixing, such as adding fentanyl to heroin.

For related information, see the Psychiatric News article “U.S. Experiences Uptick In Rates of Suicide.”

Thursday, September 7, 2017

Mental Health Provider Participation in Physician Networks Lower Than Primary Care, Study Finds


Significantly fewer mental health professionals participate in provider networks than do primary care providers, according to an analysis of Affordable Care Act (ACA) provider networks appearing in the September issue of Health Affairs. However, network participation was significantly higher among psychiatrists compared with non-physician mental health care providers, according to the study.

So-called “narrow networks” have been a prominent tool by insurers to restrict access to care. Extremely low payment rates and/or administrative burdens are often cited as reasons by providers for not participating in networks. Additionally, some insurers have advertised “phantom” networks including names of clinicians who are no longer taking new patients, have moved out of the geographical area, or, in some cases, have died. 

Jane M. Zhu, M.D., and colleagues at the University of Pennsylvania identified 531 unique provider networks offered by 281 different insurance issuers in the ACA marketplaces in all fifty states plus the District of Columbia, using a database of 5,022 on-market qualified health plans. The final analysis sample consisted of 535,114 primary care providers and 562,379 mental health care providers, of whom 51,499 were psychiatrists and 103,328 were psychologists. (The other mental health providers included nurse practitioners, physician assistants, behavioral specialists, counselors, and therapists.) 

Overall, 120,453 (21.4%) of the mental health care providers and 243,718 (45.6%) of the primary care providers in the sample participated in at least one ACA Marketplace network. Specifically, 42.7% of psychiatrists participated in at least one network compared with 58.4% of primary care physicians, a difference of 15.7 percentage points. A similar difference was observed between the two fields among non-physician providers.

“In the context of efforts to provide mental health benefits on a par with those for general medical conditions, these findings highlight important structural barriers to parity that not only necessitate provider-side interventions to encourage greater network participation, but also require consensus about and regulation of network adequacy standards,” the authors wrote.

Irvin “Sam” Muszynski, J.D., APA senior policy advisor and director of parity implementation and enforcement, said network inadequacy is a significant parity issue and an advocacy priority for the APA. “The contributing factors—provider payment rates and managed care protocols—are themselves parity issues,” he said. “Many states are grappling with this currently and the APA is working with several of them to develop a solid analytical approach to evaluating the problem respecting parity compliance.”

For more information, see the Psychiatric News article “APA Study Reveals Network Inadequacy in D.C. Exchange Plans.”

(Image: iStock/cnythzl)

Wednesday, September 6, 2017

Study Offers Clues on Increasing Resiliency in Children Exposed to Abuse


Experiencing multiple forms of abuse early in life can increase the likelihood a child will develop psychotic symptoms. A report in Schizophrenia Bulletin now suggests there are several factors that may offer some protection from this risk. According to the authors of the study, such findings could be used to inform the content or focus of interventions for at-risk youth.

The findings are based on data collected as part of the Environmental Risk Longitudinal Twin Study, which began tracking the development of a nationally representative birth cohort of 2,232 U.K.-born twins at age 5. At the start of the trial, children were given tests to assess IQ, cognitive function, and prosocial behavior. Information on household income, education, and occupation was also collected at the study start to determine family socioeconomic status (SES). The researchers assessed the children for exposure to physical maltreatment by an adult, sexual abuse, emotional abuse and neglect, bullying, and domestic violence at ages 5, 7, 10, and 12 through interviews with children, mothers, and/or direct observation. At age 12, the children were asked to report any hallucinations or delusions and complete several assessments to gauge anxiety and depression. Several measures were also used to assess the children for conduct disorder at age 12.

A total of 140 children were found to have been exposed to two or more types of victimization prior to age 12; 1,986 were exposed to one or no types of victimization. Psychotic symptoms at age 12 were more commonly reported by children who were exposed to multiple types of victimization than in those who were not (19.3% vs 4.9%, respectively)—an association that remained after controlling for SES and family history of mental health problems. A more positive atmosphere at home and relatively high IQ were associated with a reduced likelihood of psychotic symptoms emerging among children exposed to poly-victimization.

“[I]t is possible that a relatively high IQ could facilitate the development of effective coping styles that have previously been found to bolster resiliency against mental health problems, and therefore, might also be protective against the onset of psychotic symptoms,” wrote Helen Fisher, Ph.D., of King’s College London and colleagues. Additionally, “[e]ven for children where victimization does take place within the home, if there are other positive aspects to the environment, then children may be able to benefit from these, perhaps by buffering their overall stress response.” 

About 81% of the poly-victimized children did not report psychotic symptoms at age 12, but, compared with children who were not victimized, they were more likely to have conduct disorder (24.8% vs. 4.1%, respectively), depression (10.6% vs 2.3%), and extreme levels of anxiety (11.5% vs 5.0%) at age 12. 

For related information, see the Psychiatric News article “Hallucinations Can Be Marker For Variety of Psychiatric Disorders in Youth.”

(Image: iStock/Yagi-Studio)

Tuesday, September 5, 2017

CBT, Some Meds Found Effective for Anxiety in Kids, but Many Remain Symptomatic


While treatment with cognitive-behavioral therapy (CBT), selective serotonin reuptake inhibitors (SSRIs), or serotonin-norepinephrine reuptake inhibitors (SNRIs) alone appears to reduce anxiety symptoms in youth with childhood anxiety disorders, a combination of CBT and medication may be best, according to a report published in JAMA Pediatrics.

The meta-analysis involving more than 7,000 patients highlighted how different treatments fared on different measures and compared with other treatments.

Zhen Wang, Ph.D., and colleagues at the Mayo Clinic searched six large medical databases for studies comparing CBT, pharmacotherapy, or a combination to treat children and adolescents for a range of anxiety disorders.

A total of 115 studies with 7,719 patients with diagnoses of separation anxiety disorder, generalized anxiety disorder, social anxiety disorder, specific phobia, or panic disorder were included in the analyses. The medication trials included SSRIs (sertraline, fluoxetine, fluvoxamine, or paroxetine), SNRIs (atomoxetine, duloxetine, or venlafaxine), tricyclic antidepressants (clomipramine or imipramine), and benzodiazepine (clonazepam).

These were among the major findings:
  • SSRIs significantly reduced primary anxiety symptoms and increased remission and response. 
  • SNRIs significantly reduced clinician-reported primary anxiety symptoms. 
  • Benzodiazepines and tricyclics were not found to significantly reduce anxiety symptoms.
  • When CBT was compared with wait-listing/no treatment, CBT significantly improved primary anxiety symptoms, remission, and response. 
  • CBT reduced primary anxiety symptoms more than fluoxetine and improved remission more than sertraline.
  • The combination of sertraline and CBT significantly reduced clinician-reported primary anxiety symptoms and response more than either treatment alone. 
Adverse events, which were mostly not serious, were more common with pharmacotherapy than CBT. 

In an accompanying editorial, Joan Rosenbaum Asarnow, Ph.D., of the Semel Institute of Neuroscience and Behavior at UCLA, said the meta-analysis by Wang and colleagues demonstrates that there are acute treatments that work.

“Still, roughly 40% to 50% of anxious children who receive gold-standard CBT or an SSRI remain symptomatic following acute treatment,” they wrote. “While this is comparable with effects for treatments of pediatric medical conditions, such as asthma, this means that full remission is not expected for many children, even with our best treatments. Additional research and practice advances are needed to clarify how best to address this prevalent and impairing illness. The hope is that at the next review, treatments with stronger, more pervasive, and lasting benefits will be identified, with strategies for integrating these treatments within service delivery systems tested and ready to be implemented to improve behavioral health in our children.”

For related information, see the Psychiatric News article “CBT for Child Anxiety May Confer Long-term Protection from Suicidality.”

(Image: iStock/izusek)

Friday, September 1, 2017

Need for MH Services for Youth Found to Be Higher Than Previous Estimates


An estimated 1 in 10 youth in the United States is in need of psychiatric treatment or referral to mental health services, according to a study published today in Psychiatric Services.

The systematic review and meta-analysis of 12 population-based U.S. studies found that within the previous 12 months, 10.06% of youth experienced serious emotional disturbance (SED) with substantial impairment in one of more functional domains and that 6.36% of youth experienced SED with substantial impairment in two or more domains.

“The large numbers of youth and families affected by SED, the significant long-term consequences of these conditions, and the considerable costs and complexity of treating these disorders underscore the need for comprehensive and effective prevention and treatment services,” wrote Nathaniel J. Williams, Ph.D., L.C.S.W., an assistant professor in the School of Social Work at Boise State University, and colleagues.

Previous research found that 4% to 17% of youth in the United States met criteria for SED; however, each of those reviews used a unique sample and method and as a result produced unique prevalence estimates, according to the authors. The goal of this study was to determine pooled prevalence estimates of SED.

Researchers identified studies through electronic searches of the MEDLINE and PsycINFO databases and nine prior reviews. Two raters evaluated 423 full-text, peer-reviewed articles from January 1, 1980, through January 1, 2017. Studies were included if they evaluated psychopathology and functional impairment among community samples of youth aged 18 and younger in the United States using structured interviews or standardized, nationally normed rating scales. Prevalence estimates of SED with domain-specific and global impairment were extracted, along with study characteristics and case definitions. Twelve studies met the inclusion criteria.

These estimates of SED are sufficiently precise to guide clinical decision making, mental health policy, and consideration of child psychiatry workforce needs in this country, according to the investigators. They cited previous research showing that only about 50% of youth with SED receive any mental health treatment within a one-year period.

Given these estimates, an important area of concern is the shortage of child psychiatrists to provide care. “Only about 8,700 child psychiatrists deliver services in the United States, implying an untenable 620:1 ratio of youths with SED per child psychiatrist,” wrote the researchers. 

(Image: iStock/SinanAyhan)

Thursday, August 31, 2017

FDA Approves Deutetrabenazine for Treatment of Tardive Dyskinesia


Teva Pharmaceuticals Ltd. on Wednesday announced that the Food and Drug Administration has approved Austedo (deutetrabenazine) tablets for the treatment of adults with tardive dyskinesia (TD). Deutetrabenazine is a small molecule vesicular monoamine 2 transporter (VMAT2) inhibitor that has FDA approval for the treatment of chorea associated with Huntington’s disease.

The approval was based in part on the results of two 12-week, randomized, double-blind, placebo-controlled, multicenter trials, which compared changes in involuntary movements in 335 patients with TD who took deutetrabenazine or placebo. A total of 62% of the patients had concurrent diagnoses of schizophrenia/schizoaffective disorder, and 33% had a mood disorder; 86% were receiving concomitant antipsychotics.  

For the first trial, 222 patients aged 21 to 81 were randomly assigned to deutetrabenazine (12 mg/day, 24 mg/day, 36 mg/day) or placebo. Two dosage levels—24 mg/day and 36 mg/day—were associated with statistically significant improvement in patients’ Abnormal Involuntary Movement Scale (AIMS) score, from baseline to week 12, compared with placebo.

For the second trial, 113 patients aged 25 to 75 received daily doses of placebo or deutetrabenazine, starting at 12 mg/day, with titration up to 48 mg/day over a six-week period. This was followed by a six-week maintenance period at an average dose of 38.3 mg/day. From baseline to week 12, the AIMS total score decreased significantly in patients receiving deutetrabenazine compared with those receiving placebo. 

“We are pleased to bring forward this second indication for Austedo to treat the underserved tardive dyskinesia population,” Michael Hayden, M.D., Ph.D., president of Global R&D and chief scientific officer at Teva, said in a Teva press release. “We believe physicians treating tardive dyskinesia will appreciate the therapy’s dosing flexibility and the ability to focus on directly treating the movement disorder and not disrupt the ongoing treatment for the underlying condition.”

According to Teva, the most common adverse effects reported by patients taking Austedo were nasopharyngitis and insomnia. 

For more information, see the Psychiatric News PsychoPharm article “New Hope for Patients With Tardive Dyskinesia” by Stanley N. Caroff, M.D.

Wednesday, August 30, 2017

Psychotic Experiences Increase Risk of Suicidal Thoughts, Behaviors


Regardless of age, psychotic experiences can increase the likelihood that a person will think about, plan, and/or attempt suicide, according to a study published today in JAMA Psychiatry. The report also suggests that the association between psychotic episodes and suicidal thoughts and behaviors was most prominent in children aged 12 years and younger and remained statistically significant after adjusting for antecedent mental disorders and demographic factors.

“This is an important finding from a clinical point of view because it suggests that PEs [psychotic experiences] may be a predictor of subsequent STBs [suicidal thoughts and behaviors] even in individuals who do not meet criteria for mental disorders,” wrote Evelyn J. Bromet, Ph.D., of the Department of Psychiatry at Stony Brook University School of Medicine and colleagues. 

The findings were based on data derived from World Health Organization World Mental Health Surveys. Survey participants were specifically asked about hallucinatory and delusional experiences, their age when the experiences began, and the number of psychotic episodes per year. Survey participants were also asked about lifetime occurrence of suicidal ideation, suicide plans, and suicide attempts, and their age when these thoughts and/or actions first occurred. The researchers controlled for demographic factors, including the respondent’s age at time of interview, sex, and country.

Of the 33,370 adults from 19 countries surveyed, 2,488 reported psychotic experiences. Respondents with one or more psychotic episodes had twofold increased odds of subsequent suicidal thoughts and behaviors after adjusting for antecedent or intervening mental disorders (suicidal ideation: odds ratio [OR], 2.2; suicide plans: OR, 2.1; and suicide attempts: OR, 1.9). There was also a threefold to fourfold increased odds of various suicidal thoughts and behaviors in those with more frequent annualized psychotic episodes (more than 0.3 episodes per year) compared with those with less frequent annualized psychotic episodes (0.3 episodes or less per year), with ORs ranging from 3.0 for attempts to 3.8 for plans.

“From a public health perspective, we speculate that the inclusion of PE items in routine screening tools could improve the prediction of suicide risk. Our study lends additional weight to the call for the routine inclusion of PE items when assessing STBs in both research and clinical settings,” the authors concluded.

For related information, see the Psychiatric News article “Hallucinations Can Be Marker for Variety of Psychiatric Disorders in Youth.”

(Image: iStock/Gawrav Sinha)

Tuesday, August 29, 2017

Collaborative Care Increases Access, Abstinence in Patients With Opioid, Alcohol Use Disorder


A collaborative care intervention implemented at two large clinics in a Federally Qualified Health Center (FQHC) appears to have expanded access to evidence-based treatment for patients with opioid and/or alcohol use disorder (OAUD) while also increasing the number of patients achieving abstinence, according to a report in JAMA Internal Medicine.

Katherine Watson, M.D., and colleagues at RAND randomized 377 primary care patients with OAUD to either a collaborative care intervention (187) or usual care (190). The collaborative care intervention was designed to increase the delivery of either a six-session brief psychotherapy treatment and/or medication-assisted treatment with either sublingual buprenorphine/naloxone for opioid use disorders or long-acting injectable naltrexone for alcohol use disorders. (Patients with both alcohol and opioid use disorders received one or the other of the medications, based on the clinical judgment of the physician.)

Following randomization, patients in the collaborative care group met with care coordinators, who encouraged the patients to meet with a therapist for evaluation and treatment planning. These patients were entered into a registry that tracked treatment progress and prompted care coordinators to reach out to patients following missed visits. Care coordinators conducted regular assessments of substance use; results were entered into the registry and reviewed during team meetings. In contrast, patients in the usual care group were told by the research team that the clinic provided OAUD treatment and given a phone number for appointment scheduling and a list of community referrals. They did not receive any additional outreach or contact.

At six months, the proportion of participants who had received any evidence-based OAUD treatment (brief psychotherapy treatment and/or medication-assisted treatment) was higher in the collaborative care group compared with the usual care group (39% vs. 16.8%). Also at six months, a higher proportion of patients in the collaborative care group reported abstinence from opioids or alcohol (32.8% vs. 22.3%).

“These findings suggest that treatment for OAUDs can be integrated into primary care, and that primary care-based treatment is effective for OAUDs,” the researchers wrote.

APA offers training in collaborative care through a federal grant. For more information about collaborative care, see the Psychiatric News article “Reflections on Implementation of Collaborative Care” and the Psychiatric Services article “A Research Agenda to Advance the Coordination of Care for General Medical and Substance Use Disorders.”

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Monday, August 28, 2017

ADHD Symptoms May Lead Adolescent Girls to Start Smoking Early


Adolescents with more severe symptoms of attention-deficit/hyperactivity disorder (ADHD)—particularly high levels of inattention—may be more likely to start smoking cigarettes before they reach 18, according to a study published Friday in AJP in Advance. This risk of smoking was especially apparent for adolescent girls with ADHD.

“This study confirms that specific relationships between inattention and smoking observed in previous research may arise partially from causal effects, which has implications for intervention,” wrote Irene Elkins, Ph.D., of the University of Minnesota and colleagues. “Preventing nicotine exposure among females with ADHD is critical, as adolescent females may be more susceptible to nicotine’s neurotoxic effects.”

Elkins and colleagues analyzed data from three study cohorts of same-sex twins that included 3,762 individuals (52% female). They found that regardless of gender, adolescents with high inattentive symptoms were more likely to start smoking (and to do so earlier). However, unlike with adolescent boys, these symptoms were also associated with a faster progression to daily smoking, more cigarettes smoked per day, and more symptoms of nicotine dependence. 

Further, within identical twin pairs of girls, the twin with greater inattention problems was significantly more likely to smoke more, smoke daily, and develop nicotine dependence. This finding points to a possible causal influence of inattention on smoking, as identical twins have similar genetic and familial traits. This difference between identical twin pairs was not seen in boys.

Elkins and colleagues noted that the evidence of causality bolsters the idea that teenage girls with ADHD use nicotine to self-medicate their attention problems, but cautioned that even if inattention is causal, other factors may be involved. “The increased vulnerability of females to peer and academic consequences of inattention may contribute to greater depression and anxiety among inattentive females relative to inattentive males, increasing their receptivity to nicotine’s effects on attention and mood.”

For related information, see the Psychiatric News article “ADHD Diagnoses Climb Across Racial/Ethnic Groups.” 

(Image: iStock/prudkov)

Friday, August 25, 2017

Many Women Do Not Disclose Postpartum Mood Symptoms, Survey Finds

 

About 20% of women failed to disclose symptoms of postpartum mood disorder (PPMD) to their health care providers, while 46% said that barriers such as stigma and negative perception of therapy made it difficult or impossible to report such symptoms, according to the results of a survey published in this month’s Maternal and Child Health Journal.

Betty-Shannon Prevatt, M.A., L.P.A., and Sarah Desmarais, Ph.D. of North Carolina State University conducted an online survey of 211 predominantly white, middle-class women who had given birth within the past three years on their perceived barriers to psychological treatment (PBPT). The PBPT questionnaire included items in eight broad categories: stigma, lack of motivation, emotional concerns, negative evaluation of therapy, misfit of therapy to needs, time constraints, participation restrictions, and availability of services.

The participants also filled out self-reports on their socioeconomic status, depression and anxiety symptoms, stress levels, support network, and to whom they had disclosed possible PPMD symptoms.

Over half (107) of the respondents reported experiencing disrupted mood during the postpartum period, but only 52 received a mental health diagnosis from a physician. Stigma, time constraints, and lack of motivation were the most frequently reported barriers. Unemployment, history of mental illness, current depression/anxiety/stress symptoms, and self-identification of postpartum symptoms were associated with reporting more barriers.

“These findings suggest that those women most in need of treatment are also the ones who perceive the most barriers to receiving care,” the authors wrote. “Because the current sample was fairly well educated and affluent, we would expect even greater endorsement of barriers among women of more modest education and means, who are at heightened risk of PPMD.”

In contrast, higher levels of social support were associated with greater odds of symptom disclosure. “The social support networks of expectant women are underutilized resources for improving maternal mental health,” the authors wrote. “To that end, interventions should encourage women to fortify their social support network while pregnant and provide strategies for mobilizing this support during the postpartum period.”

For related information, see the Psychiatric News article “Early Postpartum Depression Screenings Not Enough to Identify High-Risk Women.”

(Halfpoint/iStock)

Thursday, August 24, 2017

Reduced Nicotine Content in Cigarettes May Decrease Addiction Potential in Vulnerable Populations


A national regulatory policy that cuts the nicotine content of cigarettes may decrease the addiction potential of cigarettes—and those effects would extend to populations highly vulnerable to tobacco addiction, according to a study published Wednesday in JAMA Psychiatry.

In late July, the Food and Drug Administration proposed reducing nicotine levels in tobacco products to decrease the chances of people becoming addicted and help currently addicted smokers to quit.

“Evidence in relatively healthy and socially stable smokers indicates that reducing the nicotine content of cigarettes reduces their addictiveness,” lead author Stephen T. Higgins, Ph.D., a professor and vice chair of psychiatry at the University of Vermont in Burlington, said in a press release. “Whether that same effect would be seen in populations highly vulnerable to tobacco addiction was unknown.”

The study consisted of a double-blind, within-participant assessment of acute response to “research cigarettes” with nicotine content ranging from levels below a hypothesized addiction threshold to those representative of commercial cigarettes (0.4 mg/g, 2.3 mg/g, 5.2 mg/g, and 15.8 mg/g of tobacco) at three academic sites. A total of 169 daily smokers (120 women, 49 men) from three vulnerable populations—people with affective disorders (n=56), people with opioid dependence (n=60), and socioeconomically disadvantaged women (n=53)—completed 14 experimental sessions lasting two to four hours each.

After smoking their usual-brand cigarette in the first session, participants smoked one research cigarette of varying doses of nicotine under double-blind conditions for sessions 2 to 5. Participants were required to use a plastic cigarette holder when smoking research cigarettes, to measure smoking topography—the number of puffs, length, and speed of each puff. A Cigarette Purchase Task was completed after each smoking session to measure the effects of cost on the participant’s rate of smoking. Additional questionnaires assessed nicotine withdrawal, smoking urges, and nicotine dependence.

For sessions 6 to 11, participants were asked to select the cigarette they preferred of two options (six different dose combinations were offered over this phase of trial). A computer program recorded which of the two cigarettes participants preferred for each session and whether or not they wanted to continue to smoke that selection after two puffs or abstain. The final phase of the trial (sessions 12-14) followed the same protocol, but measured only the highest and lowest doses of nicotine.

While participants tended to prefer the higher nicotine dose cigarettes, the researchers found that the low-nicotine dose cigarettes could serve as economic substitutes for higher-dose commercial-level nicotine cigarettes when the cost of the latter was greater.

“Reductions in reinforcing effects were achieved in the present study without causing untoward withdrawal, craving, or compensatory smoking,” Higgins and colleagues noted.

For related information, see the Psychiatric News article “Tobacco Addiction, Treatment Need More Attention by Clinicians.”

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Wednesday, August 23, 2017

Physical Comorbidities, Poor Adherence Appear Linked to Delayed Remission, Nonremission in Depression


Physical comorbidities and poor treatment adherence appear to be associated with both a failure to remit and a longer time to remission of depression, according to a report using data from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial. The findings, which were reported in Depression and Anxiety, point to the importance of interventions aimed at improving treatment adherence and addressing both the physical and mental health needs of the patient.

STAR*D, a multisite, multistep, prospective, randomized trial, compared the effectiveness of several medications or combinations of medications in adults aged 18 to 75 with major depressive disorder. Those who did not become symptom-free during one level of treatment could move the next level of treatment. Relying on data from 3,606 patients in STAR*D, Ramin Mojtabai, M.D., Ph.D., M.P.H., of Johns Hopkins University used statistical modeling to distinguish patients whose depression symptoms did not remit during the trial from those whose symptoms did remit and to characterize risk factors for each. 

According to this analysis, 14.7% of the STAR*D participants were estimated to be nonremitters. Over the course of the 12-month trial, time to remission varied considerably among remitters.

“This finding is consistent with the past research on the treatment of chronic depression and is an important consideration when deciding on the length of a new medication treatment trial for patients who have not responded to prior trials,” Mojtabai wrote. “These patients may need a longer period than the 4-8 weeks recommended in the current practice guidelines to fully respond to a treatment regimen.”

Failure to remit was significantly associated with not having a college education, current unemployment, and longer duration of depressive episode. Longer time to remission was significantly associated with seeking care at a specialty treatment setting, poorer mental health functioning assessed by the 12-item Short-Form Health Survey, and impairment in role functioning assessed by the Work and Social Adjustment Scale.

“Treatment resistance is often clinically defined by nonremission after two adequate antidepressant medication treatment trials. Yet, treatment-resistant cases are likely heterogeneous, [composed] of those who would remit in response to treatment more slowly and those who would not remit and would have a chronic course,” Mojtabai wrote. “Being able to distinguish nonremission from a longer time to remission among the remitters has important implications for understanding the causes of treatment resistance and for treatment planning.”

For related information, see the Psychiatric News article “Self-Reported Health Status May Predict Response to Depression Treatment” and the Psychiatric Services article Systematic Review of Integrated General Medical and Psychiatric Self-Management Interventions for Adults With Serious Mental Illness.


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Tuesday, August 22, 2017

"Purpose in Life" Linked to Better Physical Functioning in Older Individuals


A sense of purpose in life appears to be associated with objective measures of physical function in individuals over 50 years of age, according to a report in JAMA Psychiatry.

The study adds to a growing literature supporting “positive psychiatry”—a focus on psychological strengths such as resilience and purpose—and supports the idea that clinicians should discuss purpose of life with their older patients.  

Eric Kim, Ph.D., of the Harvard T.H. Chan School of Public Health and colleagues analyzed data from the Health and Retirement Study, an ongoing nationally representative panel study of U.S. adults older than 50 years, at two points—2006 and 2010. Purpose in life was assessed in 2006 using the seven-item Purpose in Life subscale of the Ryff Psychological Well-being Scales, in which respondents rate the degree to which they agree with a statement (for example, “Some people wander aimlessly through life, but I am not one of them”) on a six-point Likert Scale.

At both time points (2006 and 2010) hand grip strength and walking speed were assessed using standard protocols and measurement tools.

The researchers found higher baseline purpose in life was associated with decreased risk of developing slow walking speed during four years of follow-up and small increases in walking speed among people with high purpose. Higher purpose was also associated with increases in grip strength but was less robustly associated with decreased risk of developing weak grip strength.

“Although mechanisms that explain the potential health effects of purpose have not yet been clearly defined, there are likely indirect (such as, other health-related behaviors) and/or direct effects (such as, altered biological function),” Kim and colleagues wrote. “For example, people with higher purpose are more proactive in taking care of their health, have better impulse control, and engage in healthier activities.”

Past APA President Dilip Jeste, M.D. (pictured above), director of the UC San Diego Center for Healthy Aging, said the results are supportive of a large body of research emerging in the last decade showing an association between psychological well-being and measures of physical health.

Similarly, he said a robust literature has linked speed of walking and hand grip to biological age. “These two discrete measures have come to be regarded as a shorthand for biological age, a clinical marker for aging,” he said.

Finding meaning and purpose in life is especially critical—and can be challenging—for adults who have retired from jobs that for years may have served as their identity. “There’s no single answer to the purpose of life and it will be different for different people,” Jeste told Psychiatric News. “Clinicians can help with this task and should ask their older patients, ‘What’s your purpose in life?’ because patients may not bring the subject up themselves.”

For related information, see Positive Psychiatry: A Clinical Handbook, coedited by Dilip Jeste, M.D.

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