Friday, October 11, 2024

Living Situation of People With ID Does Not Appear to Influence Antipsychotic Prescribing Decisions

Individuals with intellectual disability (ID) who do not live with their family are not more likely to be prescribed antipsychotics to manage challenging behaviors like aggression, reports a study published today in Psychiatric Research and Clinical Practice.

Rather, patient sex and current medication regimen are the dominant influences overseeing prescribing decisions, noted Eion Plenn, B.A., of Penn State School of Medicine in Hershey, and colleagues.

“Previous studies have indicated that residing in group homes or other non-familial residential settings heightens the probability of being prescribed antipsychotic medications,” Plenn and colleagues wrote. However, there has been limited research directly testing the influence of living environment.

The researchers analyzed medical chart data from 112 adults with ID who received care at a regional health system from 2019 to 2021. Of this group, 55% lived with their biological family, 17% lived independently on their own, and the rest were in settings such as group homes, custodial care, or shelters. About 60% of all patients were prescribed antipsychotics, with the highest proportion of prescribing found for adults in group homes or other supported living.

However, when factoring in other demographic and medical variables, living arrangement by itself was not a significant predictor of receiving an antipsychotic. Rather, sex was the strongest predictor, with males having 4.2 times the odds of an antipsychotic prescription compared with females. Medication count was another influence, as each existing prescribed medication raised the odds of being prescribed an antipsychotic by 10%.

Plenn and colleagues also pointed out that about half the individuals with ID who were prescribed antipsychotics did not have any mental illness diagnosis. “[T]hese findings emphasize the ongoing conversations in which physicians and pharmacists bear the responsibility of thoroughly assessing the potential benefits of medication for people with ID, ensuring both its appropriateness before prescription and the realization of anticipated benefits thereafter.”

For related information, see the Psychiatric Services article “Psychotropic Use Among Youths With Intellectual and Developmental Disabilities.”

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Thursday, October 10, 2024

Most Americans Align With Family on Politics, but 1 in 5 Reports Estrangement

About 1 in 3 Americans anticipates having a heated political discussion with their family members this election season, and 6% expect family relations will get worse as a result, a new APA survey reveals.

“It is not surprising that some of us will find ourselves having heated conversations and disagreements on sensitive issues, even with the people we are close to,” said APA CEO and Medical Director Marketa M. Wills, M.D., M.B.A. “The most important thing for our collective mental health is to be mindful of how we are feeling during these tense moments, and to carefully consider the impact these interactions might be having on our important relationships.”

The survey was conducted among 2,201 adults from September 20-22 by Morning Consult. Results include:

  • 67% of respondents said they align with close family members on political issues.
  • 22% of adults said that conversations around controversial topics made them anxious, but slightly more (27%) said they enjoyed hearing different points of view.
  • 41% of respondents reported that they had argued with a family member about a controversial issue.
  • About 1 in 5 Americans reported each of the following: becoming estranged from a family member, blocking a family member on social media, or skipping a family event due to disagreements on controversial topics.

Earlier this year, the APA Council on Communications compiled tips on “How to Discuss Controversial Issues With Your Mental Health in Mind.” Among their recommendations:

  • Decide carefully when it’s time to engage. If someone says something you disagree with, take a few minutes to think about the speaker’s personality traits and whether they are likely to engage thoughtfully with you, the outcome you would want to reach, and what you might want to say.
  • Be ready to listen and consider whether you are ready to be open to someone else’s viewpoints.
  • Set some ground rules, such as agreeing to let the other person talk before you start to speak or having a true willingness to learn from the other person.

“If a conversation feels like it may be turning in a direction that will adversely impact your mental health, consider politely excusing yourself from the conversation,” Wills said. “Or consider gently steering the conversation to less intense topics where you’ll be able to find more common ground.”

For related information, see APA’s “How to Discuss Controversial Issues With Your Mental Health in Mind.”

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Wednesday, October 9, 2024

Genetic PTSD Risk Linked With Lipid Disorders, Women’s Health Issues, and More

In a large and thorough genomic analysis, researchers have found that having a genetic risk for posttraumatic stress disorder (PTSD) may also raise the risk of developing lipid-related health problems like hypercholesteremia or having an oophorectomy. Their findings were published today in the American Journal of Psychiatry.

Gita A. Pathak, Ph.D., of Yale University School of Medicine, and colleagues made use of data from the Psychiatric Genomic Consortium, which includes DNA samples from over 1 million individuals, and the UK Biobank, which in addition to genetic data includes comprehensive lifestyle and health information on more than 400,000 participants. They tested 710 lifestyle and health traits that have been linked with PTSD to see if any of these PTSD comorbidities might be due to genetic causes.

The researchers identified eight traits that are linked with genetic PTSD risk. Four of these traits were lipid-related disorders such as elevated cholesterol, elevated triglycerides, and other problems with lipid metabolism. The other four health outcomes associated with PTSD were:

  • Receiving a prescription for a malaria medication
  • Receiving a bilateral oophorectomy
  • Having a cardiac or vascular implant
  • Undergoing menopausal hormone replacement therapy

A further analysis suggested that most of these outcomes might be caused by genetic PTSD risk variants, whereas hormone replacement therapy might contribute to PTSD—although the researchers could not confirm the latter finding when running a second type of genetic analysis.

“However, a prospective study in the Nurses’ Health Study II reported that trauma and … PTSD symptoms are associated with initiating menopausal hormone therapy use in a dose-response manner,” Pathak and colleagues wrote. “The possible implication of hormone replacement therapy in PTSD pathogenesis is also supported by the effect of estrogens on fear extinction.”

The researchers also noted that some prior research in veterans suggested a connection between certain antimalarial drugs and mental health; these new findings suggest that connection may have been influenced by genetic PTSD risk.

For related information, see the American Journal of Psychiatry article “Leveraging Large-Scale Genetics of PTSD and Cardiovascular Disease to Demonstrate Robust Shared Risk and Improve Risk Prediction Accuracy," and the accompanying editorial, “From Soldier’s Heart to Shared Genetic Risk: PTSD and Cardiovascular Disease.”

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Tuesday, October 8, 2024

Stopping SSRIs/SNRIs During Pregnancy Not Tied to Adverse Outcomes in Women With Milder Symptoms

Women with mild to moderate depression or anxiety and no other mental illnesses who discontinue antidepressants during pregnancy do not appear to experience adverse psychiatric outcomes postpartum, according to a study issued today by JAMA Network Open.

“(E)vidence suggests that the severity of the maternal psychiatric burden rather than the discontinuation of antidepressants per se is associated with the risk of adverse psychiatric events,” wrote Carolyn E. Cesta, Ph.D., of the Karolinska Institutet in Stockholm, Sweden, and colleagues. Their study aimed to investigate that possibility.

Cesta and colleagues analyzed health records of 27,773 individuals in Sweden with singleton pregnancies between 2006 and 2019 who had taken at least one selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI) within 90 days of their pregnancy. Individuals with any recorded psychiatric diagnosis from a specialist in the year before pregnancy—beyond outpatient diagnoses of mild or moderate unipolar depression and anxiety—or any prescription fill in the 90 days prior for other antidepressants, antipsychotics, or antiepileptics were excluded.

Overall, 47.5% of the individuals discontinued their SSRIs/SNRIs during pregnancy while 52.5% continued taking them. The researchers assessed psychiatric-related hospitalizations as well as outpatient visits, self-harm and suicide, and any cause mortality at 90 days and 1.5 years after childbirth in both groups; they also examined sick leave usage in the 1.5 years after childbirth.

The researchers found no association between antidepressant discontinuation and adverse psychiatric-related outcomes, including outpatient visits, hospitalizations, or suicidal behavior during the 90 days or 1.5 years after childbirth. Individuals who discontinued their antidepressants during pregnancy also used fewer days of sick leave 1.5 years after childbirth compared with those in the continued use group (45 days vs. 53 days).

“Reasons for discontinuing SSRIs or SNRIs during pregnancy can include wishing to avoid fetal exposure, resolution of symptoms of depression or anxiety, or worsening of symptoms, resulting in a possible switch to other psychotropic medications,” the researchers noted. “Notably, 69.9% of individuals taking SSRIs or SNRIs before pregnancy were included in the study cohort, highlighting that this is an important patient group for which evidence on risks and benefits of SSRI or SNRI use or discontinuation in pregnancy is needed.”

For related information, see the Psychiatric News article “Neurodevelopmental Problems Not Linked to Antidepressant Exposure In Utero.”

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Monday, October 7, 2024

Masked Taper, Targeted CBT May Help Older Patients With Insomnia Discontinue Benzodiazepines

Implementing a masked taper along with targeted cognitive behavioral therapy (CBT) designed to address the placebo effect may help older patients discontinue benzodiazepine use for insomnia better than CBT and standard tapering alone, according to a study published today in JAMA Internal Medicine.

Constance H. Fung, M.D., M.S.H.S., of the VA Greater Los Angeles Healthcare System, and colleagues enrolled 188 adults ages 55 years or older who had used benzodiazepines and/or zolpidem for insomnia at doses of less than 8 mg diazepam equivalent two or more nights per week for at least three months. One group, the supervised taper group, received a paper schedule for tapering their medication over nine weeks along with a pill cutter. They also received eight sessions of standard CBT for insomnia during the nine-week taper and had periodic withdrawal check-ins.

The other group, the masked taper group, also received eight sessions of CBT for insomnia along with withdrawal check-ins. However, their CBT included additional exercises aimed at disrupting pathways thought to result in placebo effects. In essence, the exercises challenged any preconceived notions the participants may have had about whether benzodiazepines—which some studies have shown to have at least a moderate placebo effect for treating insomnia—actually helped them sleep and whether they would experience renewed insomnia or other discomfort upon discontinuing their medication.

Further, this group received their medication capsules in seven-day blister packs that, unbeknownst to the participants, contained progressively larger amounts of inert filler over nine weeks. The participants in this group were instructed to take one pill per night, with no pill cutting.

There were 179 participants at one-week posttreatment follow-up. Of those, 88.4% in the masked taper group had stopped taking their benzodiazepine, compared with 67.4% in the supervised taper group. There were 176 patients at six-month follow-up, and 73.4% in the masked taper group had stopped taking their benzodiazepine, compared with 58.6% in the supervised taper group.

“Although the 14.8% difference between groups [at six months] fell short of the 20% threshold used for power calculations, the sustained and high percentage of discontinuation, which is statistically significant and not without merit, may be attributed to our novel approach,” Fung and colleagues wrote. “The results are most applicable to individuals who use (not misuse) benzodiazepine receptor agonists for chronic insomnia disorder, can attend weekly therapy sessions and engage in prescribed homework, and are not at high risk for complicated withdrawal.”

For related information, see the Psychiatric News article “To Improve Safety in Older Patients, Consider Deprescribing.”

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Friday, October 4, 2024

Study Finds Neighborhood Diversity May Lessen Symptoms in Youth At Risk of Psychosis

Minority youth at high risk of psychosis who live in more diverse neighborhoods tend to have less severe positive symptoms—such as unusual thoughts or grandiose ideas—than those surrounded by less diversity, reports a study in Psychiatry Research.

The researchers found that part of this association was because youth in diverse neighborhoods experience less perceived discrimination and less peer victimization such as bullying.

“Numerous studies have suggested that membership in a minoritized ethnoracial group itself does not confer risk for greater psychotic symptoms, but rather exposures to unequal social environmental conditions, which disproportionately affect underrepresented youth,” wrote Benson S. Ku, M.D., of Emory University School of Medicine, and colleagues. “Our study contributes to the social determinant model of psychosis risk … shedding light on how marginalized youth might be influenced by various interlinking neighborhood and individual factors.”

Ku and colleagues used data from the North American Prodrome Longitudinal Study Phase 2, a large cohort study aimed at improving the prediction of which high-risk individuals may develop psychosis. Their analysis included 492 at-risk youth and 136 low-risk youth, with an average participant age of 18; 45% of the youth identified as an ethnoracial minority.

The researchers found that among ethnoracial minority youth at high risk of psychosis, average positive symptom severity decreased as neighborhood diversity increased—independent of neighborhood socioeconomic status. Diversity was assessed with the Simpson’s Diversity Index, which measures the probability that two people in a community chosen at random will be from different racial and ethnic groups. The association between diversity and positive symptoms was not found for at-risk White youth.

In exploring potential explanations, Ku and colleagues identified peer victimization and perceived ethnoracial discrimination as factors that mediated about 15% of the association between neighborhood diversity and positive symptom severity.

“Perhaps chronically feeling ‘different’ or being ‘othered’ in less diverse neighborhoods, along with experiencing greater victimization life events, may shape individuals’ maladaptive coping mechanisms and core beliefs and affect their social interactions with others,” the researchers wrote. “This … may lead to maladaptive social behaviors (social isolation and self-defeated attitudes) and, in turn, contribute to worsening distress and psychotic symptoms.”

For related content, see the Psychiatric News article “Review Examines How Racism May Increase Psychosis Risk.”

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Thursday, October 3, 2024

Bright Light Therapy May Boost Odds of Remission of Nonseasonal Depression

Participants who received add-on bright light therapy for nonseasonal depression, either unipolar or bipolar, were more likely to respond and reach remission than those who did not receive it, according to a systematic review and meta-analysis issued by JAMA Psychiatry.

“Bright light therapy has been studied as a potential adjunctive treatment for major depressive disorder, as light exposure is well understood to affect human mood and cognitive function,” wrote Artur Menegaz de Almeida, M.S., of the Federal University of Mato Grosso in Sinop, Brazil, and colleagues. However, they noted the efficacy of bright light therapy is only established for seasonal depression.

Menegaz de Almeida and colleagues combined data from 11 randomized trials involving 858 participants who had nonseasonal major depressive disorder or bipolar depression and used bright light therapy as adjunctive treatment to their medication. Bright light therapy was defined as using a fluorescent light box that produces white light for at least 30 minutes, with the commonly used range of 10,000 lux; the treatment length ranged from one to six weeks. All studies compared outcomes to a control group who received either an air ionizer or dim red light. Studies were published between 2000 and March 25, 2024.

In total, 60.4% of participants receiving bright light therapy responded to treatment (typically defined as a 50% or greater reduction in depressive symptoms), compared with just 38.6% of those in the control groups. Participants treated with bright light therapy also had a significantly higher remission rate than the control group (40.7% versus 23.5%, respectively). Menegaz de Almeida and colleagues also found that bright light therapy increased the likelihood that individuals could achieve a response or remission within four weeks or less.

“The primary supportive argument in favor of using bright light as an adjunctive treatment is the cost,” the authors wrote. “Even though outpatient treatment costs with antidepressants are widely variable, exposure to external light generally involves no costs or limitations, which reinforces the need to firm [bright light therapy] as an efficient adjunctive treatment for nonseasonal depressive disorders.”

For related information, see the Psychiatric Research and Clinical Practice article "Commercially Available Phototherapy Devices for Treatment of Depression: Physical Characteristics of Emitted Light."

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Wednesday, October 2, 2024

Hearing Loss Linked to Cognitive Decline; Hearing Aids Do Not Appear to Change Risk

Mild or disabling hearing loss (HL) among adults ages 45 to 69 may be associated with cognitive impairment, according to a report in JAMA Open Network. Further, wearing a hearing aid does not appear to significantly change the risk for cognitive impairment.

Baptiste Grenier, M.D., of the Universite Paris Cite, and colleagues noted that the prevalence of cognitive impairment is increasing, with up to 150 million individuals worldwide expected to be living with dementia by 2050. “Given the major burden of cognitive decline and the absence of curative treatment, identifying modifiable risk factors is of importance,” they wrote.

Grenier and colleagues analyzed data on 62,072 older participants (average age 57.4 years; 52% female) in the French CONSTANCES cohort, a population-based epidemiological cohort that recruited more than 200,000 randomly selected adults ages 18 to 69 from the French National Insurance Fund between January 1, 2012, and December 31, 2020.

Overall, 49% of participants (n = 30,624) had normal hearing, 38% (n= 23,768) had mild HL, 10% (n = 6,012) had disabling HL without use of a hearing aid, and 3% (n = 1,668) used a hearing aid; hearing status was objectively assessed with audiometric testing.

Upon enrollment, all participants ages 45 and older also underwent an extensive cognitive evaluation from trained neuropsychologists. The researchers computed a global cognitive score for the participants based on three of the tests:

  • Digit Symbol Substitution Test of attention, psychomotor speed, and reasoning
  • Free and Cued Selective Reminding Test of episodic verbal memory
  • Trail Making Test of shifting abilities and executive function

Across all ages, 27% of individuals with mild HL and 37% of those with disabling HL had global cognitive scores indicative of impairment, compared with 16% among those with normal hearing. The authors found no statistical difference in cognitive impairment risk between all individuals with disabling HL who used a hearing aid and those who did not. A secondary analysis suggested that hearing aids may reduce the risk of cognitive impairment in individuals with disabling hearing loss and depression.

The authors said that HL may cause cognitive decline because of social isolation, prolonged deprivation of auditory input, and/or shared neurodegenerative processes in the brain associated with hearing loss and cognitive deterioration. HL is also associated with loss of brain volume in critical sections of the brain.

Prescription of hearing aids for patients with disabling HL “should be guided by their established benefits on quality of life and social isolation, but not to mitigate cognitive decline for which further research is needed,” the authors wrote.

For related information, see the Psychiatric News article “Late Life Anxiety Linked to Cognitive Decline.”

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Tuesday, October 1, 2024

APA Honors and Celebrates Contributions of Hispanic, Latino Membership

Today, on National Latino Physician Day, APA is celebrating the contributions—past and present—of its Hispanic and Latino membership to the field of psychiatry.

“We applaud our bilingual, bicultural members for their commitment to educating patients and families as well as other physicians with culturally relevant resources,” said APA President Ramaswamy Viswanathan, M.D., Dr.Med.Sc. “And it is equally important to acknowledge the disparity in mental health care for Hispanics and Latinos, so that we can continue to increase access to quality care.”

Among adults with mental illness, just 40% of Latinos received mental health treatment in 2022, compared with 56% of whites, according to the Substance Abuse and Mental Health Services Administration. Factors include structural inequalities, lack of insurance, language barriers, and historical mistrust of the medical system.

APA Foundation’s Melvin Sabshin, M.D., Library and Archives recently launched “Líderes Audaces: Hispanic Pioneers in American Psychiatry,” an exhibit that highlights Hispanic leadership who have advocated for and advanced the mental health needs of the Latino community. Among other events “Líderes Audaces showcases the origins of the 1970 Task Force on Mental Health of Spanish-Speaking People in the United States, the Committee of Hispanic Psychiatrists, and the establishment of the Simón Bolívar Award in 1975 to raise awareness of the mental health goals and challenges of Hispanic and Latino individuals.

APA has also expanded its evidence-based Spanish resource website, LaSaludMental.org, which now offers information on 17 mental health conditions, including recently added sections on anxiety disorders, the connection between climate change and mental health, and Alzheimer’s disease and dementia. In the last two years, the site has been viewed hundreds of thousands of times, reaching Hispanic and Latino communities as well as the mental health professionals who serve them. The updated resource now also features a Spanish-language version of the “What Is Psychiatry?” informational page, “¿Qué es la psiquiatría?”

For related information, see the Psychiatric News article “Disparities Remain Obstacles for SUD Treatment in Hispanic/Latinx Communities.”

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