One in 10 Americans is using antidepressants--a 400 percent increase during the past 15 years, according to a new report from the CDC's National Center for Health Statistics. Further, women, especially middle-aged women, are 2.5 times more likely to be on antidepressants than men. Because of this widespread use, any potentially negative side effects from long-term antidepressant use need to be identified and discussed with patients. A good source of information is What Your Patients Need to Know About Psychiatric Medications, Second Edition, published by American Psychiatric Publishing.Image: Maria Sbytova/Shutterstock.com