---
title: "Psych News Alert: Gene Variant Predicts Antidepressant Response and Side Effect Severity"
description: A variant in a gene called ABCB1 can predict how a person will respond to certain antidepressants, reports a new study in AJP in Advance ...
image: https://alert.psychnews.org/hubfs/Imported_Blog_Media/DNA%20variant_10448176-Jun-24-2025-07-17-37-8026-PM.jpg
---

 3/30/15 12:00 AM

# Gene Variant Predicts Antidepressant Response and Side Effect Severity

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A variant in a gene called ABCB1 can predict how a person will respond to certain antidepressants, reports a new study in *AJP in Advance* titled “[ABCB1 Genetic Effects on Antidepressant Outcomes: A Report From the iSPOT-D Trial](http://ajp.psychiatryonline.org/doi/full/10.1176/appi.ajp.2015.14050680).”

The study involved 683 patients who received escitalopram, sertraline, or extended-release venlafaxine; the participants also had their ABCB1 gene sequenced. All three of these medications interact with P-glycoprotein, the protein encoded by the ABCB1 gene that functions in transporting antidepressants across the blood-brain barrier.

The authors found a variant called rs10245483 had a significant effect on remission rate and side effects, though it varied depending on the medication. People who had two copies of the common variant (G/G) responded better and had fewer side effects with escitalopram and sertraline. In contrast, people with the minor variant (T/T) responded better and had fewer side effects with venlafaxine.

The degree of remission correlated with the relative cognition of the patient. G/G participants had a greater rate of remission with escitalopram if their cognition was intact, whereas people with T/T displayed a greater rate of remission with venlafaxine if their cognition was impaired.

To read about a potential pharmacogenetic biomarker that may help inform sobriety treatment, see the *Psychiatric News* article “[Genetic Analysis Identifies Possible Acamprosate Biomarker](http://psychnews.psychiatryonline.org/doi/full/10.1176/appi.pn.2014.12a18).”

(shutterstock/appler)

[Venlafaxine](https://alert.psychnews.org/tag/venlafaxine), [antidepressant](https://alert.psychnews.org/tag/antidepressant), [sertraline](https://alert.psychnews.org/tag/sertraline), [escitalopram](https://alert.psychnews.org/tag/escitalopram), [pharmacogenetics](https://alert.psychnews.org/tag/pharmacogenetics)

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