--- title: "Psych News Alert: Epigenetic Changes May Link Socioeconomic Status With Altered Brain Function, Depression" description: Although lower socioeconomic status is associated with an increased risk of mental illness, including anxiety and depression, little is k... image: https://alert.psychnews.org/hubfs/Imported_Blog_Media/DNA-blue_134698571-Jun-24-2025-05-40-55-1656-PM.jpg --- 1/26/17 12:00 AM # Epigenetic Changes May Link Socioeconomic Status With Altered Brain Function, Depression ![Picture of Psychiatric News Alert](https://alert.psychnews.org/hs-fs/hubfs/Psych%20News%20Email%20Banners/PN-Blue-Box_rgb.png?width=50&name=PN-Blue-Box_rgb.png) [ Psychiatric News Alert ](https://alert.psychnews.org/author/psychiatric-news-alert) Share: [facebook-f icon ](http://www.facebook.com/share.php?u=https://alert.psychnews.org/2017/01/epigenetic-changes-may-link.html) [linkedin-in icon ](http://www.linkedin.com/shareArticle?mini=true&url=https://alert.psychnews.org/2017/01/epigenetic-changes-may-link.html) [Twitter icon ](https://twitter.com/intent/tweet?url=https://alert.psychnews.org/2017/01/epigenetic-changes-may-link.html) [pinterest-p icon ](http://pinterest.com/pin/create/link/?url=https://alert.psychnews.org/2017/01/epigenetic-changes-may-link.html) [envelope icon ](mailto:?body=https://alert.psychnews.org/2017/01/epigenetic-changes-may-link.html) | ![](https://alert.psychnews.org/hs-fs/hubfs/Imported_Blog_Media/DNA-blue_134698571-Jun-24-2025-05-40-56-9825-PM.jpg?width=200&height=133&name=DNA-blue_134698571-Jun-24-2025-05-40-56-9825-PM.jpg) | | | --- | --- | Although lower socioeconomic status is associated with an increased risk of mental illness, including anxiety and depression, little is known of the biological processes that may mediate this association. A [study](http://www.nature.com/mp/journal/v22/n2/abs/mp201682a.html) appearing in *Molecular Psychiatry* suggests a biological pathway through which lower socioeconomic status may contribute to altered brain function and future risk of depression.  “[I]f replicated, the risk pathway identified here could represent a discrete biomarker that could be targeted by novel strategies for personalized treatment and prevention,” Johnna Swartz, Ph.D., a postdoctoral associate in the Department of Psychology and Neuroscience at Duke University, and colleagues wrote. For the study, the researchers analyzed epigenetic, neuroimaging, and behavioral data collected from 132 youth who were participants in the Teen Alcohol Outcomes Study (a multiyear study examining the association between the development of depression and alcohol use disorders in adolescence). Adolescents were between 11 and 15 years old during the first wave of data collection, 13 and 18 at Wave 2, and 14 and 19 at Wave 3. Lower socioeconomic status—as defined by parental education and income—at Wave 1 predicted greater increase in methylation of the proximal promoter region of the serotonin transporter gene SLC6A4 two years later (Wave 2), with or without a family history of mental illness. Analysis of fMRI data revealed that increases in SLC6A4 methylation from Wave 1 to Wave 2 were also associated with increases in threat-related amygdala reactivity over the same period. In adolescents with a positive family history of depression, greater increases in reactivity from Wave 1 to Wave 2 prospectively predicted greater increases in depressive symptoms from Wave 2 to Wave 3; there was no such relationship in adolescents without a family history of depression. “It is possible that these high-risk adolescents experience additional forms of chronic adversity such as parental neglect or familial discord uncommon among their low-risk counterparts and that this additional exposure is necessary to trigger symptoms of depression,” Swartz and colleagues concluded. “[O]ur results identify a specific biological pathway through which broader environmental adversity may act to drive individual vulnerability for depression among at-risk adolescents.” For related information, see the *Psychiatric News* article “[Researchers Tackle Complexity of Intergenerational Stress Transmission](http://psychnews.psychiatryonline.org/doi/full/10.1176/appi.pn.2016.1b9).” (Image: vitstudio/Shutterstock) --- ### Have You Voted in APA’s 2017 Election Yet? Learn about this year’s slate of candidates, their priorities, and backgrounds at the [APA elections page](http://www.psychiatry.org/psychiatrists/awards-leadership-opportunities/leadership-opportunities/elections) and watch video interviews of the candidates for president-elect and secretary. Voting closes on Tuesday, **January 31**. Click [here](http://paracom.paramountcommunication.com/ct/39972589:siXuGylFN:m:1:339349070:4B426350A934AD95ABA26675A8B84D64:r) to vote now and be part of the process. [psychiatry](https://alert.psychnews.org/tag/psychiatry), [amygdala](https://alert.psychnews.org/tag/amygdala), [epigenetics](https://alert.psychnews.org/tag/epigenetics), [socioeconomic status](https://alert.psychnews.org/tag/socioeconomic-status), [methylation](https://alert.psychnews.org/tag/methylation) ## Related posts [![](https://alert.psychnews.org/hs-fs/hubfs/Imported_Blog_Media/cms1-Jun-24-2025-03-46-59-0336-PM.jpg?height=200&name=cms1-Jun-24-2025-03-46-59-0336-PM.jpg) ](https://alert.psychnews.org/2022/03/more-research-needed-on-appropriateness.html) [Medicare](https://alert.psychnews.org/tag/medicare), [psychiatrists](https://alert.psychnews.org/tag/psychiatrists), [CMS](https://alert.psychnews.org/tag/cms), [JAMA Health Forum](https://alert.psychnews.org/tag/jama-health-forum), [value-based program](https://alert.psychnews.org/tag/value-based-program), [cancer screening](https://alert.psychnews.org/tag/cancer-screening), [performance](https://alert.psychnews.org/tag/performance), [depression screening](https://alert.psychnews.org/tag/depression-screening), [MIPS](https://alert.psychnews.org/tag/mips) ## [More Research Needed on Appropriateness of MIPS Measures for Psychiatrists, Study Shows](https://alert.psychnews.org/2022/03/more-research-needed-on-appropriateness.html) ![Picture of Psychiatric News Alert](https://alert.psychnews.org/hs-fs/hubfs/Psych%20News%20Email%20Banners/PN-Blue-Box_rgb.png?width=50&name=PN-Blue-Box_rgb.png) [Psychiatric News Alert](https://alert.psychnews.org/author/psychiatric-news-alert) 6/24/24 11:16 AM [ Read more ](https://alert.psychnews.org/2022/03/more-research-needed-on-appropriateness.html) [![](https://alert.psychnews.org/hs-fs/hubfs/Imported_Blog_Media/teen_girls_iStock-489587887-Jun-24-2025-03-51-20-8598-PM.jpg?height=200&name=teen_girls_iStock-489587887-Jun-24-2025-03-51-20-8598-PM.jpg) ](https://alert.psychnews.org/2019/04/population-study-finds-link-between.html) ## [Population Study Finds Link Between Childhood Infections and Later Eating Disorders](https://alert.psychnews.org/2019/04/population-study-finds-link-between.html) ![Picture of Psychiatric News Alert](https://alert.psychnews.org/hs-fs/hubfs/Psych%20News%20Email%20Banners/PN-Blue-Box_rgb.png?width=50&name=PN-Blue-Box_rgb.png) [Psychiatric News Alert](https://alert.psychnews.org/author/psychiatric-news-alert) 4/25/19 12:00 AM Severe infection in childhood was associated with a significantly increased risk of being diagnosed... [ Read more ](https://alert.psychnews.org/2019/04/population-study-finds-link-between.html) [![](https://alert.psychnews.org/hs-fs/hubfs/Imported_Blog_Media/gastric%20bypass%20surgery_93594667-4.jpg?height=200&name=gastric%20bypass%20surgery_93594667-4.jpg) ](https://alert.psychnews.org/2012/06/increase-in-alcohol-use-follows-popular.html) [alcohol use disorder](https://alert.psychnews.org/tag/alcohol-use-disorder), [bariatric surgery](https://alert.psychnews.org/tag/bariatric-surgery) ## [Increase in Alcohol Use Follows Popular Form of Surgery](https://alert.psychnews.org/2012/06/increase-in-alcohol-use-follows-popular.html) ![Picture of Psychiatric News Alert](https://alert.psychnews.org/hs-fs/hubfs/Psych%20News%20Email%20Banners/PN-Blue-Box_rgb.png?width=50&name=PN-Blue-Box_rgb.png) [Psychiatric News Alert](https://alert.psychnews.org/author/psychiatric-news-alert) 6/19/12 12:00 AM Physicians are finding a surprising link between an increasingly popular form of surgery and... [ Read more ](https://alert.psychnews.org/2012/06/increase-in-alcohol-use-follows-popular.html) ```json { "@context" : "https://schema.org", "@type" : "BlogPosting", "author" : { "@type" : "Person", "name" : "Psychiatric News Alert", "url" : "https://alert.psychnews.org/author/psychiatric-news-alert" }, "dateModified" : "2025-06-24T17:44:26.849Z", "datePublished" : "2017-01-26T05:00:00.000Z", "headline" : "Psych News Alert: Epigenetic Changes May Link Socioeconomic Status With Altered Brain Function, Depression", "image" : [ "https://alert.psychnews.org/hubfs/Imported_Blog_Media/DNA-blue_134698571-Jun-24-2025-05-40-55-1656-PM.jpg" ], "mainEntityOfPage" : { "@id" : "https://alert.psychnews.org/2017/01/epigenetic-changes-may-link.html", "@type" : "WebPage" }, "publisher" : { "@type" : "Organization", "logo" : { "@type" : "ImageObject", "url" : "https://alert.psychnews.org/hubfs/PN-Blue-Box.jpg" } } } ```