--- title: "Psych News Alert: Cytisinicline May Help People Quit Vaping" description: Cytisinicline—a plant-based chemical—can help people stop using e-cigarettes when paired with behavioral support, a study in JAMA Internal... image: https://alert.psychnews.org/hubfs/Imported_Blog_Media/vaping-iStock-1176085829-Jun-24-2025-09-15-38-1118-PM.jpg --- 5/14/24 12:00 AM # Cytisinicline May Help People Quit Vaping ![Picture of Psychiatric News Alert](https://alert.psychnews.org/hs-fs/hubfs/Psych%20News%20Email%20Banners/PN-Blue-Box_rgb.png?width=50&name=PN-Blue-Box_rgb.png) [ Psychiatric News Alert ](https://alert.psychnews.org/author/psychiatric-news-alert) Share: [facebook-f icon ](http://www.facebook.com/share.php?u=https://alert.psychnews.org/2024/05/cytisinicline-may-help-people-quit.html) [linkedin-in icon ](http://www.linkedin.com/shareArticle?mini=true&url=https://alert.psychnews.org/2024/05/cytisinicline-may-help-people-quit.html) [Twitter icon ](https://twitter.com/intent/tweet?url=https://alert.psychnews.org/2024/05/cytisinicline-may-help-people-quit.html) [pinterest-p icon ](http://pinterest.com/pin/create/link/?url=https://alert.psychnews.org/2024/05/cytisinicline-may-help-people-quit.html) [envelope icon ](mailto:?body=https://alert.psychnews.org/2024/05/cytisinicline-may-help-people-quit.html) ![](https://alert.psychnews.org/hs-fs/hubfs/Imported_Blog_Media/vaping-iStock-1176085829-Jun-24-2025-09-15-37-1022-PM.jpg?width=200&height=133&name=vaping-iStock-1176085829-Jun-24-2025-09-15-37-1022-PM.jpg) Cytisinicline—a plant-based chemical—can help people stop using e-cigarettes when paired with behavioral support, a [study](https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2818194) in *JAMA Internal Medicine* reports. Compared with individuals who received placebo along with behavioral support, those who received cytisinicline had twice the rate of vaping abstinence after 12 weeks. “While these findings warrant confirmation in a phase 3 trial with a larger sample size and longer follow-up, they are consistent with the demonstrated efficacy of cytisinicline for cigarette [smoking cessation](https://jamanetwork.com/journals/jama/article-abstract/2807079),” wrote Nancy Rigotti, M.D., of Harvard Medical School and colleagues. “For individuals seeking to quit vaping, cytisinicline might fill the existing gap in pharmacologic treatments and enhance the emerging evidence of efficacy of behavioral treatments for vaping cessation.” Rigotti and colleagues enrolled 160 adults who used e-cigarettes but not regular cigarettes and wanted to quit vaping. Of these participants, 107 took 3 mg of cytisinicline three times daily for 12 weeks while the other 53 took identical placebo pills. All participants received 10 minutes of vaping-cessation support each week from trained counselors. At these weekly visits, the participants also reported their e-cigarette use over the prior week and provided a saliva sample to measure cotinine, a nicotine metabolite. After 12 weeks, 31.8% of the participants who took cytisinicline achieved continuous vaping abstinence (defined as four weeks without vaping, confirmed with cotinine measurements), compared with 15.1% of those who took placebo. The researchers found no evidence that variables like age, sex, race, degree of e-cigarette dependence, or preferred e-liquid flavor affected the participants’ ability to abstain. Four participants left the study because of adverse events; the most common side effects reported were abnormal dreams, insomnia, anxiety, headache, and fatigue. Cytisinicline did not appear to contribute to cigarette smoking. Rates of regular cigarette smoking were similar in the cytisinicline and placebo groups at the end of the study. “While the present trial is an important step toward developing effective e-cigarette treatments, there is much more to be done,” wrote Suchitra Krishnan-Sarin, Ph.D., and Lisa Fucito, Ph.D., of Yale School of Medicine in an accompanying [editorial](https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2818201). “E-cigarette technology is constantly evolving to include novel nicotine forms, flavorants, and device configurations to deliver nicotine palatably, rapidly, and at high levels, which likely exceeds delivery of nicotine from cigarettes. The efficacy of medications like cytisinicline for people with greater addiction from the use of these novel e-cigarettes may be diminished.” For related information, see the *Psychiatric News* special report, “[Vaping—A Call to Action for Psychiatrists](https://psychnews.psychiatryonline.org/doi/10.1176/appi.pn.2023.08.8.1).” (Image: Getty Images/iStock/Bulat Silvia) --- ### Open Payments Review and Dispute Period Ends Tomorrow [Open Payments](https://www.cms.gov/priorities/key-initiatives/open-payments), CMS’ national disclosure program, promotes transparency into financial relationships between pharmaceutical and medical device companies and health care providers. The program allows providers an opportunity to review, affirm, and if necessary, dispute payments attributed to them by these companies before they are made public. The review and dispute period ends on **Wednesday, May 15**. Open Payments encourages all covered providers to review the reported data to ensure their information is accurate prior to publication. Get started by [registering here](https://portal.cms.gov/portal/) and learn more at [OpenPaymentsData.cms.gov](https://openpaymentsdata.cms.gov/). [addiction](https://alert.psychnews.org/tag/addiction), [smoking](https://alert.psychnews.org/tag/smoking), [abstinence](https://alert.psychnews.org/tag/abstinence), [clinical trial](https://alert.psychnews.org/tag/clinical-trial), [vaping](https://alert.psychnews.org/tag/vaping), [nicotine](https://alert.psychnews.org/tag/nicotine), [E-cigarette](https://alert.psychnews.org/tag/e-cigarette) ## Related posts [![](https://alert.psychnews.org/hs-fs/hubfs/Imported_Blog_Media/psilocybin_iStock-2154591716.jpg?height=200&name=psilocybin_iStock-2154591716.jpg) ](https://alert.psychnews.org/one-psilocybin-dose-can-lead-to-prolonged-smoking-cessation) [smoking](https://alert.psychnews.org/tag/smoking), [nicotine patch](https://alert.psychnews.org/tag/nicotine-patch), [smoking cessation](https://alert.psychnews.org/tag/smoking-cessation), [abstinence](https://alert.psychnews.org/tag/abstinence), [psychedelic](https://alert.psychnews.org/tag/psychedelic), [psilocybin](https://alert.psychnews.org/tag/psilocybin), [quitting smoking](https://alert.psychnews.org/tag/quitting-smoking) ## [One Psilocybin Dose Can Lead to Prolonged Smoking Cessation](https://alert.psychnews.org/one-psilocybin-dose-can-lead-to-prolonged-smoking-cessation) ![Picture of Psychiatric News Alert](https://alert.psychnews.org/hs-fs/hubfs/Psych%20News%20Email%20Banners/PN-Blue-Box_rgb.png?width=50&name=PN-Blue-Box_rgb.png) [Psychiatric News Alert](https://alert.psychnews.org/author/psychiatric-news-alert) 3/10/26 12:16 PM A single dose of psilocybin is significantly better than a nicotine patch at helping people quit... [ Read more ](https://alert.psychnews.org/one-psilocybin-dose-can-lead-to-prolonged-smoking-cessation) [![](https://alert.psychnews.org/hs-fs/hubfs/Imported_Blog_Media/quit_smoking_iStock-698143352-Jun-24-2025-10-32-57-2938-PM.jpg?height=200&name=quit_smoking_iStock-698143352-Jun-24-2025-10-32-57-2938-PM.jpg) ](https://alert.psychnews.org/2025/04/new-drug-shows-promise-for-helping.html) [cigarettes](https://alert.psychnews.org/tag/cigarettes), [smoking](https://alert.psychnews.org/tag/smoking), [varenicline](https://alert.psychnews.org/tag/varenicline), [bupropion](https://alert.psychnews.org/tag/bupropion), [nicotine](https://alert.psychnews.org/tag/nicotine) ## [New Drug Shows Promise for Helping Patients Quit Smoking](https://alert.psychnews.org/2025/04/new-drug-shows-promise-for-helping.html) ![Picture of Psychiatric News Alert](https://alert.psychnews.org/hs-fs/hubfs/Psych%20News%20Email%20Banners/PN-Blue-Box_rgb.png?width=50&name=PN-Blue-Box_rgb.png) [Psychiatric News Alert](https://alert.psychnews.org/author/psychiatric-news-alert) 4/23/25 12:00 AM [ Read more ](https://alert.psychnews.org/2025/04/new-drug-shows-promise-for-helping.html) [![](https://alert.psychnews.org/hs-fs/hubfs/Imported_Blog_Media/vaping_iStock-1366587827.jpg?height=200&name=vaping_iStock-1366587827.jpg) ](https://alert.psychnews.org/states-banning-flavored-e-cigarettes-reduced-initiation-by-young-adults) [addiction](https://alert.psychnews.org/tag/addiction), [smoking](https://alert.psychnews.org/tag/smoking), [adolescents](https://alert.psychnews.org/tag/adolescents), [young adults](https://alert.psychnews.org/tag/young-adults), [vaping](https://alert.psychnews.org/tag/vaping), [nicotine](https://alert.psychnews.org/tag/nicotine), [nicotine use disorder](https://alert.psychnews.org/tag/nicotine-use-disorder), [NUD](https://alert.psychnews.org/tag/nud) ## [States Banning Flavored E-Cigarettes Reduced Initiation by Young Adults](https://alert.psychnews.org/states-banning-flavored-e-cigarettes-reduced-initiation-by-young-adults) ![Picture of Psychiatric News Alert](https://alert.psychnews.org/hs-fs/hubfs/Psych%20News%20Email%20Banners/PN-Blue-Box_rgb.png?width=50&name=PN-Blue-Box_rgb.png) [Psychiatric News Alert](https://alert.psychnews.org/author/psychiatric-news-alert) 1/5/26 3:31 PM Young people living in one of four states with flavoring bans for e-cigarettes were only half as... [ Read more ](https://alert.psychnews.org/states-banning-flavored-e-cigarettes-reduced-initiation-by-young-adults) ```json { "@context" : "https://schema.org", "@type" : "BlogPosting", "author" : { "@type" : "Person", "name" : "Psychiatric News Alert", "url" : "https://alert.psychnews.org/author/psychiatric-news-alert" }, "dateModified" : "2025-06-24T21:18:01.409Z", "datePublished" : "2024-05-14T04:00:00.000Z", "headline" : "Psych News Alert: Cytisinicline May Help People Quit Vaping", "image" : [ "https://alert.psychnews.org/hubfs/Imported_Blog_Media/vaping-iStock-1176085829-Jun-24-2025-09-15-38-1118-PM.jpg" ], "mainEntityOfPage" : { "@id" : "https://alert.psychnews.org/2024/05/cytisinicline-may-help-people-quit.html", "@type" : "WebPage" }, "publisher" : { "@type" : "Organization", "logo" : { "@type" : "ImageObject", "url" : "https://alert.psychnews.org/hubfs/PN-Blue-Box.jpg" } } } ```